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You can read the abstract of this article atEffects of Exercise, Diet and Weight Loss on High Blood Pressure PubMed (nih.gov) Obesity and being obese are strongly correlated with arterial hypertension, also referred to as high blood pressure

Some people experience mild digestive upset during or after treatment things like cramping, bloating, or nausea

In a sensitivity analysis using a less conservative statistical approach, there was significant benefit on fatal and nonfatal MI (HR 0.91, 95% CI 0.831.00