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While residing in the nucleus the PDHc is constitutively repressed by a scaffolding component of the mitotic deacetylase complex identified as ELMSAN1 (ELM2SANT domaincontaining scaffolding protein 1)
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The binding interaction studies highlight critical active site residues in PDE1B (L388, F424, H373, F392, and Q421) and PDE10A (F729, I692, F696, Y683, F719, and Q726), which are key determinants for ligand binding and selectivity
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