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Formononetin-loaded self-microemulsion drug delivery systems for improved solubility and oral bioavailability: fabrication, characterization, in vitro and in vivo evaluation

Across all incretin-based therapies, gastrointestinal adverse effects are the most commonly reported side effects

By activating the JNK signaling pathway, IL-1 significantly upregulates the pro-apoptotic protein Bax, subsequently inducing apoptosis in cerebrovascular endothelial cells and ultimately compromising BBB function through dual mechanisms: disrupting structural integrity and promoting cell death (102)

There are also several GLP-1 RAs that are approved for treating diabetes