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FADD, via its death effector domain activates initiator caspase-8, which subsequently activates effector caspases (caspase-3, -6, and -7), culminating in apoptotic cell death (96, 99101)
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Gali M, et al
Notably, human clear cell renal cell carcinomasa lipid-rich malignancyexhibit elevated levels of chondroitin sulfate and increased lipoprotein-derived -toc compared with normal kidney tissue
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