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Pro-Hyp, Hyp-Gly) act as signaling molecules that stimulate fibroblast activity and increase endogenous collagen synthesis Supports reductions in collagenase/gelatinase enzyme activity, which helps limit connective tissue breakdown and improves skin elasticity and hydration Best For: Skin elasticity/anti-aging support, joint pain and cartilage maintenance, and general connective tissue and tendon-ligament recovery Typical Protocol: 1 g/day has been used in trials for skin hydration and elasticity (RCT, PMC6073484), while 5-15 g/day is the range studied for joint health and muscle recovery, with 15 g/day showing greater benefit than 5 g/day (systematic review, PMC8521576)

Collagen is the most abundant protein in the human body, and it decreases as we age, leading to the formation of wrinkles and fine lines

These findings underscore the real-world clinical relevance of the three-protein panel, as it not only maintains high discriminative accuracy but also generates actionable risk stratification that could support individualized interventions, even in populations with relatively low sPTB prevalence