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The breakthrough for cagrilintide was applying the fatty acid acylation technology that made semaglutide viableattaching a fatty acid chain to a modified amylin analog backbone that prevents aggregation while enabling extended albumin binding
Blackwell TK, Steinbaugh MJ, Hourihan JM, Ewald CY, Isik M (2015) SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans
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