In patients with mild cognitive impairment (often a precursor to Alzheimers disease), prolonged melatonin supplementation reportedly slowed the progression of cognitive decline and improved sleep and mood, though larger trials are needed
However, optimal results depend on professional supervision, realistic expectations, and consistent maintenance

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The available research suggests that the most important nutritional side effects of GLP-1 drugs include inadequate protein intake, loss of lean muscle mass, vitamin D deficiency, B-vitamin problems including thiamine, iron depletion, anemia, and low intake of key minerals like calcium, magnesium, and potassium