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In patients with heart failure, it is also possible that SGLT2-inhibitor-mediated improvements in cardiac function could translate into improved exercise capacity (a recent meta-analysis suggests a modest 20 m improvement in 6-min walk distance with SGLT2 inhibitors in patients with heart failure [162], and hence into increased physical activity with consequent benefit on deconditiong

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Anuria or acute renal insufficiency Spironolactone is contraindicated in patients with complete absence of urine production or acute renal failure, as it can exacerbate fluid and electrolyte imbalance

Only five people gained back a small amount