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If someone loses 40 pounds but a large chunk of that is lean mass, they may end up smaller but weaker, flatter, more tired, and more prone to regain once appetite comes back or the medication changes
Launching oral GLP-1s requires more than extending injectable playbooks
For example, a patient who struggles with constant hunger may benefit most from a GLP-1 therapy, while someone who eats primarily in response to stress or emotion may respond better to a medication that targets neurological reward pathways
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