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Modulating Fas signaling in Th2 cells is necessary for suppressing type 2 inflammation
Leveraging the acidic milieu in OA, researchers introduce acid sensitive groups (amino, carboxyl, thiol) or protonatable and acid labile linkages (esters, Schiff bases, vinyl ethers) into drug loaded matrices to achieve condition triggered degradation and precise, on demand release of anti-inflammatory agents ( Leveraging the large surface area, tunable functionality, high drug-loading capacity, and pH sensitivity of ZIF-8 metalorganic frameworks (MOFs), Yu et al
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