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In these trials, MOUNJARO (5 mg, 10 mg, and 15 mg given subcutaneously once weekly) was compared with placebo, semaglutide 1 mg, insulin degludec, and/or insulin glargine [see Clinical Studies (14.2, 14.3, 14.4)]
The mechanisms potentially contributing to cardiovascular protection may include effects on weight, glycemic control, blood pressure, and possibly direct effects on vascular inflammation and lipid metabolism, though these mechanisms remain under investigation
This will provide an important theoretical basis for targeted metabolic interventions to enhance anti-tumor immune response
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