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The positive effects of IGF-1 on the rats continued for months after the rats stopped getting the supplemental hormone, whereas the exercising rats immediately lost size and strength as soon as they stopped exercising. In another study the muscle fibers of 27-month old rats old age for rats that were given IGF-1 during middle age, exhibited no deterioration of muscle fibers that indicate the classic and inevitable signs of aging

Food and Drug Administration, (2022), "FDA approves treatment for weight management in patients with Bardet-Biedl Syndrome aged 6 or older"

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Potential Side Effects The SURMOUNT clinical trials showed that the most common adverse events can include: Diarrhea Constipation Vomiting More severe side effects could include kidney failure, allergic reactions, changes in vision, pancreatitis, and others