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Hippocampal neurons are particularly affected, linking calcium dysregulation to paradoxical memory impairment (97, 98)
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Cyclisation in Melanotan II flattens that profile, giving comparable potency at MC1R and MC4R and only modestly less at MC3R and MC5R, which is why Melanotan II is used as the non-selective positive control while Melanotan 1 is used where an MC1R-weighted reference agonist is wanted
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