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Brain Res 1187 , 116124, (2008)
Abbreviations HCC: Hepatocellular carcinoma AAAs: Aromatic amino acids Trp: tryptophan Tyr: tyrosine Phe: phenylalanine Phe: Phenylalanine Leu: leucine Ile: isoleucine Val: valine Glu: glutamate Ala: alanine Arg: Arginine Gln: glutamine PAH: phenylalanine hydroxylase 5-HT: 5-hydroxytryptamine (serotonin) Kyn: kynurenine AADC: aromatic L-amino acid decarboxylase TDO: tryptophan 2,3-dioxygenase IDO1: indoleamine 2,3-dioxygenase 1 IDO2: indoleamine 2,3-dioxygenase 2 AhR: aryl hydrocarbon receptor QuinA: quinolinic acid TCA: tricarboxylic acid TAT: tyrosine aminotransferase GSTZ1: glutathione S-transferase zeta 1 FAH: fumarylacetoacetate hydrolase MAA1: maleylacetoacetate isomerase FAA: fumarylacetoacetate BCATs: branched-chain amino acid aminotransferases BCKAs: branched-chain -keto acids -KG: -ketoglutarate BCKDH: branched-chain -keto acid dehydrogenase BCKDK: branched-chain -keto acid dehydrogenase kinase KIC: -ketoisocaproic acid KIV: -ketoisovaleric acid KMV: -ketomethylvaleric acid GLS: glutaminase GSH: glutathione GDH: glutamate dehydrogenase References Llovet JM, Kelley RK, Villanueva A, Singal AG, Pikarsky E, Roayaie S, et al
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