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Clinical Trial Evidence: Landmark cardiovascular outcome trials (CVOTs) like the SELECT trial (for semaglutide) have shown a significant reduction in major adverse cardiovascular events (MACE), including heart attack, stroke, and cardiovascular death
Summary: GLP-1 receptor agonists are not licensed for anxiety treatment and lack established evidence for direct anxiolytic effects, though some patients may experience secondary psychological improvements through metabolic health gains
Ipamorelin (GHRP, activates GHSR-1a on somatotrophs) and CJC-1295 (GHRH analog, activates GHRHR on somatotrophs) stimulate growth hormone release through two complementary receptor pathways on the same pituitary cell type
But they also represent one of the most significant cost risks to employer health insurance plans heading into the 2026 renewal cycle
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