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Oveporexton Dosing# Side Effects Comparison# DSIP Side Effects# Limited safety data exists for DSIP: Occasional headache reported in small studies Morning grogginess at higher doses No systematic adverse event reporting No long-term safety data available No anti-drug antibody or immunogenicity testing Oveporexton Side Effects# From Phase 2 and Phase 3 clinical trials: Oveporexton was generally well-tolerated with a safety profile consistent across the Phase 2b, FirstLight, and RadiantLight studies
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Patients with recurrent depression exhibit reduced hippocampal volume and hippocampal atrophy in the brain when compared to healthy controls ( Figure 2 ) (Sheline et al., 1999)
