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For example, the SELECT trial clearly demonstrated that semaglutide significantly reduces the risk of major adverse cardiovascular events (MACE), leading to FDA approval for lowering the risk of cardiovascular death, myocardial infarction, or stroke in overweight or obese adults with established cardiovascular disease ( ) for reducing the risk of kidney failure and disease progression in patients with diabetes and chronic kidney disease (CKD), making it the first GLP-1 agent indicated for the treatment of CKD (Perkovic et al., 2024)
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The candidate showed statistically significant reductions in body weight compared with placebo, with up to 14.7% weight loss after 13 weeks of patients taking the drug
-Wrinkles: The loss of natural hyaluronic acid is one of the primary causes of wrinkles, so the idea of putting HA back into the skin to repair wrinkles makes sense
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