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The structure-activity relationship (SAR) studies conducted by Chugai and subsequently by Eli Lilly explored modifications across the molecule's three principal domains: the tetrahydropyran ring system, the indazole heterocycle, and the substituted phenyl ring

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[1] It is also known as tetra-substituted GRF (1-29), and is composed of a sequence thought to be the smallest necessary to interact with GHRH receptors, specifically the first 29 amino acids of GHRH

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