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In animal models, researchers measure parameters such as circulating free fatty acids, respiratory exchange ratios, and adipose tissue gene expression to characterize shifts in substrate utilization
Several papers describe upregulation of the vascular endothelial growth factor receptor 2 ( VEGFR2 ) pathway and downstream nitric oxide signalling the so-called VEGFR2-Akt-eNOS axis which researchers hypothesise underlies its reported influence on wound healing and blood-flow restoration at an injury site
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