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I mean, it was tobacco
Vigorous agitation generates shear forces and an air-liquid interface that promote peptide aggregation, and it produces foam that traps material away from the solution
[2] During a monotherapy clinical trial of topiramate in the treatment of epilepsy in adults, hypertonia was reported in 0% of patients receiving 50 mg/day and 3% of patients receiving 400 mg/day
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