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MT-IIs activation of MC3R and MC4R in mesolimbic dopamine circuits , including the ventral tegmental area and nucleus accumbens and modulates dopamine release and dopamine receptor signalling in reward and motivation circuits

Patients with needle anxiety often prefer oral options, accepting the slightly higher monthly investment

Additionally, bitter foods like rocket (arugula) and polyphenols found in berries and green tea help activate the gut receptors responsible for hormone release

Start with just a tsp of fiber rich food or a pinch of a slow fermenting soluble fiber supplement (PHGG) and gradually increase as tolerated