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GI side effects (nausea, reduced appetite, occasional digestive discomfort) are most pronounced during this period

Mitochondria are also involved in key cellular functions such as Ca 2 + homeostasis, heme biosynthesis, nutrient metabolism (Cheng and Ristow, 2013), steroid hormone biosynthesis, removal of ammonia, integration of metabolic and signaling pathways for cell death and autophagy (Hammerman et al., 2004

Amino acids play a vital role in supporting immune function by serving as substrates for the synthesis of immune-related proteins, antibodies, cytokines, and signalling molecules

2a, the cumulative incidence of composite outcomes was consistently higher in the GLP-1RA group compared to the DPP-4i group, demonstrating a statistically significant increased risk in the former, with a log-rank p value of less than 0.001