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It is characterized by excessive accumulation of reactive oxygen species (ROS) that surpasses the bodys intrinsic scavenging capacity
Karsdal, Morten A
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In addition, GSH depletion induced SIPS, as evidenced by increased percentage of the senescence-associated -galactosidase-positive cells, increased senescence-associated heterochromatin foci (SAHF), as well as cell cycle arrest at the G1 phase
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