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The tripeptide modulates over 4,000 human genes (31.2% of the genome) and plasma levels decline from approximately 200 ng/mL at age 20 to less than half by age 60 (Pickart & Margolina, 2018)
Taurine as osmoregulator and neuromodulator in the brain
This pace was enabled by several factors: the strength and consistency of the Phase 2 efficacy signals, Eli Lilly's extensive infrastructure for metabolic disease trials built through the tirzepatide program, the availability of well-characterized biomarkers and endpoints for obesity and diabetes, and the increasing regulatory receptivity to obesity treatments as the field matured
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