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Clinical evidence suggests that combining metformin with GLP-1 agonists like semaglutide may enhance overall metabolic benefit, especially for patients with insulin resistance or elevated blood sugar
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A healthy lifestyle complements the medications benefits and promotes overall well-being
Guideline impact: The 2026 ESC guidelines now extend PCSK9i recommendations to primary high-risk prevention (Class I, Level A) [71] (Table 4)
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