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Nat Rev Microbiol (2022) 20:73749

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Preclinical toxicological data: Acute and subacute toxicity studies in rats did not reveal any mortality or significant organ toxicity, even at doses well above therapeutic doses (up to 100 times the effective dose)

ProHealth extends this architecture by adding both a postbiotic (directly delivered butyrate via ButyroGen) and a peptide (BPC-157) that pre-clinical animal research suggests may support the gastrointestinal environment - a mechanism the brand describes based on its own published references, not as an established human clinical outcome