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Adults assigned semaglutide had a lower risk for major kidney disease events and cardiovascular events compared with those assigned placebo

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What this looks like in practice Synthesizing across the conversations, the clinical playbook for nutrition on GLP-1s in 2026 looks roughly like this: Protein floor : 1.01.2 g/kg, higher for older patients or those building muscle Build meals protein-first : choose the protein, then the vegetable, then the carb Resistance training : 23 sessions per week, progressive Fiber : 2535 g per day, mostly from food Hydration : 80+ oz of water per day Tracking : optional but useful for ensuring composition, not for restricting intake Eat slowly : stop at fullness, which arrives early Long-term thinking : build the eating pattern you want to keep, not the one you can tolerate while medicated This is a substantially more nuanced playbook than the one in circulation a year ago

The specific mechanism may be by activating VEGF-A / VEGFR1 -mediated AKT and p38/MAPK signaling pathways to upregulate downstream eNOS expression, which may increase the NO product synthesis thus promote angiogenesis of gastric mucosa, and also interact with ER stress