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Conceptual Origin: From Empirical Observation to Theoretical Framework In the 16th century, the Swiss physician Paracelsus established the philosophical foundation for dose-response relationships with his statement, The dose makes the poison ( Sola dosis facit venenum )
During pregnancy, expired prenatal supplements may fall short on folic acid and DHAkey for fetal neural development
Patients with ME/CFS often experience various symptoms beyond fatigue, such as post-exertional malaise (PEM), orthostatic intolerance, sleep disturbances, muscle pain, headaches, and cognitive difficulties [3]
Similarly, synthetic cathinones mimic the effects of traditional stimulants but exhibit heightened potency and toxicity
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