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2 Weight loss pharmacotherapies 2.1 GLP-1R and GIPR agonism reduce body weight in patients with obesity Early GLP-1R agonists were approved to treat T2D (13, 15, 16), but the potential weight lowering efficacy for this class of molecules first seen in rodents was not confirmed in humans until clinical trials with the first long-acting GLP-1 analogue, liraglutide (12)
The muscle is injected with the medication (known as an intramuscular injection)
By co-culturing neurons and astrocytes, the methylation of the GLT-1 promoter is reduced (Yang et al., 2010)
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