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This drug class, known as GLP-1 agonists, includes semaglutideapproved as Ozempic for type 2 diabetes and Wegovy for obesityand tirzepatideapproved as Mounjaro for diabetes and Zepbound for obesity
The compound is derived from a sequence associated with gastric protective proteins, which has made it a subject of interest across a broad range of preclinical research models
In its native state, PEPITEM consists of a chain of 14 amino acids, but in this most recent study, researchers led by Professor Ed Rainger from the University of Birmingham and Professor Francesco Maione from the University of Naples Federico II, looked for, and identified the smallest parts of the PEPITEM molecule that influence immune cells and inflammation in psoriasis
CiteSeerX 10.1.1.516.9510
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