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However, because GLP-1 customers generate roughly four times the mARPU of core subscribers, the outflow is modest in subscriber numbers but disproportionately large in revenue terms

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Energy minimization was conducted with the steepest descent method (maximum force tolerance of 1000 kJmolnm, step size 0.01 nm), followed by 100 ps NVT equilibration (0310.15 K) and 100 ps NPT equilibration (310.15 K, 1 bar) using the Berendsen barostat

The mechanistic difference explains why individual responses vary significantly