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TRIUMPH-4 showed 28.7% weight loss (completed December 2025), which predicts substantial liver benefits, but liver fat wasn't directly measured as a primary endpoint
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The Child-Pugh classification system (classes A, B, and C) stratifies hepatic impairment severity and guides dose adjustments for most pharmaceuticals [5]
It is a hormone secreted by the L-cells of the small intestine and the distal colon exerting its effects through interaction with the GLP-1 receptor, expressed in the islets, the lungs, the hypothalamus, the stomach, the heart and the kidneys
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