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The use of the Ca 2+ -sensitive receptor (CaSR) inhibitor NPS-2143 can block the carnitine-induced increase in the cytoplasmic Ca 2+ concentration, indicating that carnitine-induced Ca 2+ mobilization is mediated by the activation of CaSR [119]

The DREAM program of Phase 3 trials is evaluating mazdutide specifically for type 2 diabetes management across multiple dosing regimens

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