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The peptides physical identity is commonly summarized as follows: sequence GEPPPGKPADDAGLV, molecular formula C62H98N16O22, molecular weight approximately 1,419.56 Da, and CAS number 137525-51-0

1 Its endogenous ligand is GLP-2 (GLP-2(133)), a member of the glucagon-like peptide family that also includes GLP-1 and glucagon

Astrocytes play a central role in maintaining CNS homeostasis through purinergic signaling, wherein extracellular ATP and its degradation product adenosine modulate synaptic activity, inflammation, and neuronal excitability via purinergic P2X, P2Y, and adenosine receptors [324, 326]

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