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The 24 individuals with obesity were taking a maintenance dose of GLP-1RA medication for weight loss ( N = 14, GLP-1RA group) for at least 30 days, or not taking any medication for weight loss ( N = 10, control group)
GLP-1 medications can cause fatigue through several mechanisms including reduced caloric intake due to appetite suppression, gastrointestinal side effects leading to dehydration and electrolyte imbalances, and metabolic adjustment to improved blood glucose control
However, the safety and efficacy of such combinations require careful evaluation
This does not mean stopping is always wrong some people reach a healthy weight and maintain it successfully through lifestyle changes but it underscores the importance of having a professional plan in place
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