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Burning Sensation in Chest While burning sensation in chest is most commonly acid reflux or heartburn, you should eliminate more serious conditions like: Angina (inadequate blood supply to the heart) Heart attack Costochondritis (inflammation of cartilage of the rib cage) As chest burning sensation may be mimicking a cardiac pattern, you need to present in the emergency room in case there is burning that is followed by dizziness, breathlessness, or radiation of pain