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Thus, additional experiments could be conducted to systematically explore the effects of sulfonylureas on other ion channels besides K ATP channels, especially for some channels such as Kv2.1, which are closely linked to insulin release in -cells ( 2+ -dependent inhibition of K ATP by sulfonylureas, such as tolbutamide and glibenclamide, is evident, suggestive of the importance of Mg 2+ in the impact of sulfonylureas on ion channels, and it may be factored into devising related experiments