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We observed significant changes in metabolic pathways in response to diet in females, with some overlap in the response to DL and CR feeding, while males showed many fewer changes with no overlapping changes between the DL and CR groups

Some randomized trials and responder analyses reported improvements in triglycerides and other metabolic measurements

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This metabolism, which is oriented toward the synthesis of phosphoadenosine phosphosulfates from homocysteine thiolactone sulfur atoms, might lead to an excessive sulfation of extracellular matrix proteoaminoglycans