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The observational nature of the study and lack of a comparator arm mean that other explanations for the changes in HbA 1c and body weight, such as changes in medication throughout the study, cannot be excluded
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For researchers, this highlights the need to stratify outcomes not only by dose but also by starting weight, ensuring that comparisons across arms are meaningful
In addition, the enteric nervous system can act as a relay from the gut to the brain
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