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HLC cultures were incubated with conventional probe substrates for CYP3A4 (6 M midazolam), CYP2C9 (10 M diclofenac), and CYP2D6 (10 M dextromethorphan) for 2 hours

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Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors

We suppose the change is because the initial doses are enough to keep B12 levels within the desired range