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Patients should contact their GP or diabetes team if they experience: Severe, persistent abdominal pain (potential pancreatitis) Persistent vomiting leading to dehydration Signs of hypoglycaemia (if taking alongside insulin or sulphonylureas) Severe or persistent constipation or abdominal distension Right upper quadrant pain, fever or jaundice (potential gallbladder problems) Sudden visual changes (especially in those with diabetic retinopathy) Allergic reactions or injection site problems Weight loss typically becomes noticeable within the first few weeks to months, though the rate varies considerably between individuals
Zhu et al., 2014)
Weekly injections deliver consistent medication exposure, helping stabilize appetite signals and blood sugar throughout each week
Understanding your genetic predisposition profile does not predict your exact response to branded versus compounded semaglutide, but it can inform your provider's reasoning for recommending consistency, dose adjustments, or alternative GLP-1 pathways
