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Mixing high-concentration L-ascorbic acid (pH below 3.5) with GHK-Cu in the same application risks copper reduction and free-radical generation, a chemistry problem most cosmetic content ignores

Pickart estimated the toxic dose for humans at approximately 22,500 mg, which sits roughly 3,750 times higher than a typical weekly therapeutic dose

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Therefore, the considerable effects observed may not reflect or ameliorate all the conditions that make up metabolic syndrome, including abdominal obesity, high blood glucose, high blood sugar, high LDL levels, and low HDL levels