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Everyones situation is different, but most people who have pernicious anemia take vitamin B12 supplements for the rest of their lives
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[13] Chloramphenicol has been shown to blunt reticulocyte response to cyanocobalamin, while ethanol, colchicine, and nitrous oxide interfere with cobalamin metabolism or utilization, each warranting clinician awareness when evaluating suboptimal treatment outcomes
There is also no strong efficacy argument for rushing: in REDEFINE 2 only 61.9% of patients were on the full 2.4 mg at the end of the trial and the group still averaged 13.7%
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