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Research investigations focus on understanding individual variation in senescent cell accumulation and responses to senolytic administration, providing foundation for developing personalized approaches to senescence research
4,5 Deficient GSH synthesis has been associated with oxidative stress in aging, 6 and GSH concentrations decrease with age, a factor thought to explain, in part, why the elderly are at greater risk of neurodegenerative diseases
In contrast, for simvastatin, the IC50 value in HEB was significantly higher than that in glioblastoma cell lines (Fig
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