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However, because the receptor is already strongly stimulated by the GLP-1 receptor agonist, even if endogenous GLP-1 or GIP is increased with a DPP-4 inhibitor, almost no additional blood glucose-lowering effect can be expected
PKA phosphorylates the transcription factor MITF (microphthalmia-associated transcription factor), upregulating tyrosinase and melanogenic enzymes
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