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This modification slows the drugs breakdown by enzymes, extending how long it stays active in the body
That was a major turning point
We account for quality of life improvements associated with expanded access to AOMs using Generalized Risk-Adjusted Cost-Effectiveness (GRACE), which (unlike traditional cost-effectiveness) complies with Inflation Reduction Act prohibitions on Centers for Medicare & Medicaid Services use of discriminatory value assessment methods
This is supported by recent studies from US and German adults with T2D, which reported that the use of GLP-1RAs versus insulin resulted in lower emergency room visits and inpatient admissions but higher drug acquisition costs after treatment initiation [49, 50]
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