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Published preclinical studies use it as a chemical tool to investigate NNMT activity, nicotinamide metabolism, cellular methyl-donor balance, NAD-related pathways, and adipocyte biology in cell and animal models

The most studied is GHK-Cu, a naturally occurring copper peptide first identified in the human body

Another RCT found a decrease in homocysteine with 1000 g hydroxo-B12 monthly for 3 months by 2 mol/l, whilst the control group had a 2 mol/l increase, although the difference was not statistically significant

This injectable formulation allows for much higher plasma concentrations of vitamin C, bypassing the limitations of gastrointestinal absorption and providing rapid systemic availability