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Current Clinical Guidance Related to Noncirrhotic NASH/MASH Preclinical Models of Steatotic Liver Disease European Association for the Study of the Liver (EASL) May 2026 Semaglutide Therapy for Metabolic Dysfunction-Associated Steatohepatitis American Association for the Study of Liver Diseases (AASLD) November 2025 Evaluation and Management of Metabolic Dysfunction-Associated Steatotic Liver Disease in Children American Association for the Study of Liver Diseases (AASLD) March 2025 Risk Stratification and Management of Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease American Gastroenterological Association (AGA) March 2026 Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in People with Diabetes: The Need for Screening and Early Intervention American Diabetes Association (ADA) May 2025 Resmetirom Therapy for Metabolic Dysfunction-Associated Steatotic Liver Disease American Association for the Study of Liver Diseases (AASLD) October 2024 Management of Metabolic Dysfunction-Associated Steatotic Liver Disease European Association for the Study of Diabetes (EASD), European Association for the Study of the Liver (EASL), European Association for the Study of Obesity (EASO) June 2024 Recent FDA Approvals Related to Noncirrhotic NASH/MASH Below are medications recently approved by the FDA that we anticipate being incorporated into future clinical guidelines: Novo Nordisk August 2025 For the treatment of noncirrhotic metabolic dysfunction- associated steatohepatitis (MASH), formerly known as nonalcoholic steatohepatitis (NASH), with moderate to advanced liver fibrosis (consistent with stages F2 to F3 fibrosis) in adults

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