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In some experiments, HEK-Blue Null1 as the parental cell line of HEK-Blue hTLR9 cells was used as a control, where cells pretreated with ENDO3 or ENDO12 (1 or 10 M) were stimulated with TNF (100 ng ml 1 )
If fatigue emerges despite adequate nutrition and biomarker supplementation, dose reduction or temporary pause may be warranted
Second, the etiological heterogeneity observed in pediatric and pregnant populations underscores the need for more individualized prevention and management approaches
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