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Beyond their effectiveness in glycemic control, these therapies also promote weight loss, making them beneficial for patients with overweight or obesity alongside type 2 diabetes
The Kat6a null allele was generated as described previously, with the deletion of 5 exons (exons 48 of 17 exons in NM_001364449.1 and exons 59 of 18 exons in NM_001081149.2) resulting in a premature stop codon in the catalytic domain (Voss et al, 2009)
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Male mice were used to eliminate the confounding effects of the estrous cycle-related hormonal fluctuations on vascular and metabolic parameters
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